Deep Brain Stimulation for Treatment Resistant Depression
common.study.values.description
“Deep Brain Stimulation for Treatment Resistant Depression”
Treatment resistant depression (TRD) is a major global health concern, and there is a crucial need to develop novel effective treatments. The medial forebrain bundle (MFB) is a recently described DBS target, with reported rapid onset of antidepressant effects. A recent small randomized trial reported a 100% response rate. The subcallosal cingulate cortex (SCC) is the most commonly used target in DBS for depression. Herein, the investigators will conduct a sham-controlled randomized trial of DBS to the MFB or SCC for TRD.
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participant.ui.study.affiliations-map.online-study.header-virtual
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common.study.values.methods
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Device - Active stimulation of the medial forebrain bundle or subcallosal cingulate
Deep brain stimulation of the medial forebrain bundle or subcallosal cingulate
Device - Sham stimulation
Sham stimulation for 2 weeks (Cross-over design)
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Deep Brain Stimulation of the Medial Forebrain Bundle and Subcallosal Cingulate for the Treatment of Treatment Resistant Depression
common.study.values.clinical-trial-id
NCT04009928
participant.views.study.view.id
e5yv8e
