Eligibility Details:
Inclusion Criteria:
1. Have provided voluntary written informed consent.
2. Adult male or female, 18 to 55 years of age, inclusive, at Screening.
3. Continuous nonsmoker who has not used nicotine containing products for at least 3
months prior to the first dosing and throughout the study.
4. Have a body mass index (BMI) of ≥ 18.0 and ≤ 32.0 kg/m^2 at Screening.
5. Medically healthy with no clinically significant medical history, physical
examination, laboratory profiles, vital signs, or ECG. Liver function tests (serum
alanine aminotransferase [ALT], aspartate aminotransferase [AST], alkaline phosphatase
[ALP], and bilirubin [total and direct]) must be ≤ the upper limit of normal (ULN).
6. Female participants must be of nonchildbearing potential defined as a female who has
undergone one of the following sterilization procedures at least 6 months prior to the
first dosing: hysteroscopic sterilization; bilateral tubal ligation or bilateral
salpingectomy; hysterectomy; bilateral oophorectomy. Or is postmenopausal with
amenorrhea for at least 1 year prior to the first dosing and follicle-stimulating
hormone (FSH) serum levels consistent with postmenopausal status.
7. A nonvasectomized, male participant must agree to use a condom with spermicide or
abstain from sexual intercourse during the study until 90 days after the last dosing.
(No restrictions are required for a vasectomized male provided his vasectomy has been
performed 4 months or more prior to the first dosing of study drug. A male who has
been vasectomized less than 4 months prior to study first dosing must follow the same
restrictions as a nonvasectomized male).
8. Male participants must agree not to donate sperm from the first dosing until 90 days
after the last dosing.
9. Understands the study procedures in the informed consent form (ICF), and be willing
and able to comply with the protocol.
10. Additional Criteria for Japanese participants only: be first-generation Japanese,
defined as meeting all of the following conditions: born in Japan; has 2 Japanese
biological parents and 4 Japanese biological grandparents; has lived outside of Japan
for <5 years; has made no significant changes in lifestyle, including diet, since
leaving Japan.
11. Additional Criteria for Non-Asian participants only: Non-Asian participants will have
2 biological parents and 4 biological grandparents of Non-Asian descent.
Exclusion Criteria:
1. Mentally or legally incapacitated or has significant emotional problems at the time of
the Screening visit or expected during the conduct of the study.
2. History or presence of clinically significant medical or psychiatric condition or
disease in the opinion of the Investigator or designee.
3. History of any illness that, in the opinion of the Investigator or designee, might
confound the results of the study or pose an additional risk to the participant (eg,
history or presence of rashes) by their participation in the study.
4. History of stomach or intestinal surgery that would potentially alter
absorption/secretion; or any major surgical procedure within the previous 3 months
prior to Screening.
5. History of severe and/or uncontrolled ventricular arrhythmias, or other factors that
increase the risk of QT prolongation or arrhythmic events (eg, heart failure,
hypokalemia, family history of long QT interval syndrome).
6. History or presence of alcoholism or drug abuse within the past 2 years prior to the
first dosing.
7. History or presence of hypersensitivity or idiosyncratic reaction to the study drugs
or related compounds.
8. Any positive responses on the Columbia-Suicide Severity Rating Scale (C-SSRS).
9. Female participants of childbearing potential.
10. Female participants with a positive pregnancy test or who are lactating.
11. Positive urine drug or alcohol results at Screening or Day -1/Day 21.
12. Positive results at Screening for human immunodeficiency virus (HIV) antibodies,
hepatitis B surface antigen (HbsAg), or hepatitis C virus (HCV) antibodies.
13. QTcF interval is >450 msec, or QRS interval >110 msec, or PR interval >220 msec, or
participants who have ECG findings deemed abnormal with clinical significance by the
Investigator or designee at Screening.
14. Supine blood pressure is less than 90/40 mmHg or greater than 140/90 mmHg at
Screening.
15. Supine heart rate is lower than 40 beats per minute (bpm) or higher than 99 bpm at
Screening.
16. Estimated creatinine clearance <90 mL/min at Screening.
17. Unable to refrain from or anticipates the use of: any drug, including prescription and
non-prescription medications, herbal remedies, and vitamin supplements, beginning 14
days prior to the first dosing and throughout the study. After first dosing,
acetaminophen (<2 g per 24 hour) may be administered at the discretion of Investigator
or designee. Hormone replacement therapy will not be allowed; any drugs known to be
strong inducers of CYP3A, CYP2C9, or CYP2C19 enzymes including St. John's Wort and/or,
gastric acid reducing agents (eg, protonpump inhibitors, H2-receptor antagonists,
antacids) for 28 days, or drugs that can prolong the QT interval for 28 days, prior to
the first dosing and throughout the study. Appropriate sources (eg, Flockhart TableTM)
will be consulted to confirm lack of PK/Pharmacodynamic (PD) interaction with study
drug.
18. Refuses to abstain from alcohol from 48 hours prior to the first dosing and throughout
the study.
19. Refuses to abstain from grapefruit-containing foods or beverages or Seville orange
containing foods or beverages from 14 days prior to the first dosing and throughout
the study.
20. Donation of blood or significant blood loss within 56 days prior to the first dose.
21. Plasma donation within 7 days prior to the first dose.
22. Receipt of blood or blood products within 2 months prior to the first dose.
23. Participation in another clinical study within 30 days prior to the first dose. The
30-day window will be derived from the date of the last blood collection or dosing,
whichever is later, in the previous study to Day 1 of Period 1 of the current study.
common.study.methods.has-drugs-yes
common.study.methods.is-healthy-no
