Eligibility Details:
Inclusion Criteria:
- Men aged 18-35 years
- Ability to understand verbal or written instructions/testing materials in English
- Physically active (as determined by accelerometry and review of a physical activity
log)
- Not taking any prescription medications and/or willing to refrain from all medication
use prior to and throughout the entire study period, unless provided/approved by the
study physician
- Willing to refrain from alcohol, smoking, e-cigarettes or use of any nicotine product,
caffeine, and dietary supplement use throughout the entire study period
- Willing to live on the Pennington Biomedical Research Center inpatient unit for 20
consecutive days
- Meets age-specific US Army body composition standards according to Army Regulation
600-9, which includes estimates of percent body fat based on height, weight, and
circumference measures (neck and waist)
- Total testosterone concentration is within the normal physiological range (300-1,000
ng/dL)
Exclusion Criteria:
- Musculoskeletal injuries that compromise exercise capability
- Diagnosed cardiometabolic disorders (i.e., hypertension, hyperlipidemia, kidney
disease, diabetes, etc.)
- Allergies or intolerance to foods, vegetarian practices, or history of complications
with lidocaine
- Anabolic steroid, human growth hormone, or nutritional testosterone precursor-like
supplement use within the past 6 months
- Will not refrain from smoking (any nicotine product), alcohol, caffeine, or any other
dietary supplement during the study
- Adults unable to consent
- Women
- Prisoners
- Sedentary or engages in insufficient quantities of physical activity per week (aerobic
and/or resistance training as determined by accelerometry and review of a physical
activity log)
- Exceeds age-specific US Army body composition standards according to Army Regulation
600-9
- Previous history of kidney stones unless otherwise approved by the medical
investigator
- Systolic blood pressure > 150 or diastolic blood pressure > 95 mmHg
- Previous history of breast or prostate cancer
- Previous history of Chronic Obstructive Pulmonary Disease or Obstructive Sleep Apnea
- Prostate-Specific Antigen (PSA) > 3ng/ml, Hematocrit > 50%, or positive urine drug
screening
- Based on the investigative team's clinical judgment, a subject may not be appropriate
for participation in the study