Eligibility Details:
Inclusion Criteria:
1. Men and women, aged 21-55 years
2. Willing and able to give voluntary written informed consent
3. Able to read and write English and communicate effectively with the investigators, and
comply with all study requirements, restrictions, and directions of the clinic staff
4. Moderate Drinkers will report consuming alcohol on at least one occasion in the past
three months that would result in an estimated blood alcohol level greater than 100
mg/dl but not meet DSM-5 criteria for AUD. This is to ensure that subjects have prior
drinking exposure consistent with levels proposed in this study. Prospective subjects
will be asked to recall the heaviest two days of drinking in the previous three
months. Using this information, approximate BAC will be calculated for those prior
episodes.
5. Medically healthy upon physical examination and laboratory testing.
Exclusion Criteria:
1. Individuals whom the investigators deem may not be able to comply with alcohol
abstinence for 48 hours prior to study day.
2. Current significant medical condition such as neurological, cardiovascular, endocrine,
renal, liver, or thyroid pathology.
3. History of or current neurological or significant psychiatric disorder such as
schizophrenia or bipolar disorder (DSM-5 Axis 1).
4. Other substance use disorder with the exception of nicotine dependence in smokers as
assessed with the SCID or positive urine screen for drugs of abuse.
5. Participants with any significant current medical conditions that would contraindicate
the consumption of alcohol, such as history of neurological trauma or diseases,
seizures, delirium or hallucinations, hepatic, or other unstable medical conditions.
6. Current suicidal or homicidal intent or behavior, or history of suicidal or homicidal
behavior.
7. No barbiturates or other known microsomal enzyme induces or inhibitors in the past
month.
8. History of significant head trauma.
9. Women who are pregnant or nursing or fail to use one of the following methods of birth
control unless she or partner is surgically sterile or she is postmenopausal (hormone
contraceptives [oral, implant, injection, patch, or ring], contraceptive sponge,
double barrier [diaphragm or condom plus spermicide], or IUD).
10. Regular or current significant use of any prescription, herbal or illegal psychotropic
medications (e.g., antidepressants, antipsychotics, anxiolytics, ecstasy) in the past
6 mo, with no current illegal drug use confirmed by urine toxicology (except for
cocaine and marijuana when relevant).
11. Have MRI-incompatible implants and other contraindications for MRI, such as a
pacemaker, artificial joints, non-removable body piercings, claustrophobia, etc.
12. Subjects with history of prior radiation exposure for research purposes within the
past year such that participation in this study would place them over FDA limits for
annual radiation exposure. This guideline is an effective dose of 5 rem received per
year.
13. Subjects with current, past or anticipated exposure to radiation in the work place
within one year of proposed research PET scans.
14. Subjects with history of IV drug use which would prevent venous access for PET tracer
injection.
15. Blood donation within eight weeks of the start of the study
16. History of blooding disorder or currently taking anticoagulants (such as Coumadin,
Heparin, Pradaxa, Xarelto).
common.study.methods.has-drugs-yes
common.study.methods.is-healthy-no
