Eligibility Details:
Inclusion Criteria:
- Informed consent obtained from the participant.
- Age: 19-35 years of age at enrollment or 55-72 years of age at enrollment.
- Gender: males and females included.
- Right-handed based on the Edinburgh Handedness Inventory
- Cognitive functioning: IQ of 85 - 115 on the Wechsler Adult Intelligence Scale-Revised
- Ability to complete the questionnaires in English, as not all the neuropsychological
tests and questionnaires have been validated in other languages.
Exclusion Criteria:
- Current use of the following medications: psychotropic medications or other
medications with significant CNS effects (e.g., antipsychotics, psychostimulants,
anticonvulsants, alpha-agonists, adrenergic blockers, lithium, and sedating
antihistamines), or other excluded medication.
- Current psychiatric diagnosis based on the Mini-International Neuropsychiatric
Interview (MINI) and/or the adult attention-deficit/hyperactivity disorder (ADHD)
diagnostic interview.
- Current substance abuse or substance dependence at any time.
- The presence of a known neurological disorder or any major medical illness or injury
impacting neurological/psychiatric function (e.g., diabetes, epilepsy, cerebral palsy,
traumatic brain injury, significant environmental/toxic injury, neurodegenerative
disorder, past meningitis/encephalitis).
- General medical conditions: any major medical conditions that would interfere with
involvement in the study or may affect CNS function as judged by the investigative
team.
- History of clinically-significant head trauma.
- Pregnancy
- Any other condition that, in the opinion of the investigator, is a contraindication to
participation
- The presence of any ferrous metal implant, including orthodonture, which may interfere
with the MEG data acquisition and/or be anMRI safety concern.
- Inability to correct visual acuity to 20/20 with corrective lenses (we can correct
from +5 to -6 diopters in .5 diopter steps, separately for each eye, with non-magnetic
corrective lenses in the laboratory).