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Racial Differences in Vasoconstriction

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The Effect of Local Antioxidant Therapy on Racial Differences in Vasoconstriction

The goal of this study is to examine possible mechanisms of heightened vasoconstriction in Black/African American men and women as possible links to the elevated prevalence of cardiovascular dysfunction and disease. The main targets in this study are sources of oxidative stress.

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Pharmaceutical medication involved common.study.methods.has-drugs-yes
Patients and healthy individuals accepted common.study.methods.is-healthy-no

Drug - Control (Phenylephrine)

This intervention is aimed at assessing the vascular responsiveness to phenylephrine, an alpha 1-agonist, in white and black men and women across a series of ascending dose concentrations.

Drug - Phenylephrine + Apocynin

This intervention is meant to assess the impact of NADPH oxidase-derived superoxide on vasoconstrictor responses by inhibiting the enzyme NADPH oxidase.

Drug - Phenylephrine + Allopurinol

This intervention is meant to assess the impact of xanthine oxidase-derived superoxide on vasoconstrictor responses by inhibiting the enzyme xanthine oxidase.

Drug - Phenylephrine + Tempol

This intervention is meant to assess the impact of superoxide on vasoconstrictor responses by scavenging available superoxide.

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The Effect of Local Antioxidant Therapy on Racial Differences in Vasoconstriction

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NCT03680404

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