Racial Differences in Vasoconstriction
common.study.values.description
“The Effect of Local Antioxidant Therapy on Racial Differences in Vasoconstriction”
The goal of this study is to examine possible mechanisms of heightened vasoconstriction in Black/African American men and women as possible links to the elevated prevalence of cardiovascular dysfunction and disease. The main targets in this study are sources of oxidative stress.
common.study.values.location
participant.ui.study.affiliations-map.online-study.header-virtual
participant.ui.study.affiliations-map.online-study.text
common.study.values.methods
common.study.methods.has-drugs-yes
common.study.methods.is-healthy-no
Drug - Control (Phenylephrine)
This intervention is aimed at assessing the vascular responsiveness to phenylephrine, an alpha 1-agonist, in white and black men and women across a series of ascending dose concentrations.
Drug - Phenylephrine + Apocynin
This intervention is meant to assess the impact of NADPH oxidase-derived superoxide on vasoconstrictor responses by inhibiting the enzyme NADPH oxidase.
Drug - Phenylephrine + Allopurinol
This intervention is meant to assess the impact of xanthine oxidase-derived superoxide on vasoconstrictor responses by inhibiting the enzyme xanthine oxidase.
Drug - Phenylephrine + Tempol
This intervention is meant to assess the impact of superoxide on vasoconstrictor responses by scavenging available superoxide.
participant.views.study.view.additional
participant.views.study.view.scientific-title
The Effect of Local Antioxidant Therapy on Racial Differences in Vasoconstriction
common.study.values.clinical-trial-id
NCT03680404
participant.views.study.view.id
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