Early Life Microbiome and Diet in Crohn's Disease
common.study.values.description
“Modulating Early Life Microbiome Through Dietary Intervention in Crohn's Disease”
The MELODY Trial: Modulating Early Life Microbiome through Dietary Intervention in Crohn's Disease, will test whether a non-invasive dietary intervention during pregnancy can improve the gut microbiota composition in both pregnant Crohn's disease patients and their babies during the sensitive time window of infant immune system development, and whether this can lead to decreased risk of maternal disease relapse postpartum and decreased functional gastrointestinal disorders and gut inflammation in their babies. Through this trial, the study team hopes to better understand the origin of the initial gut bacterial colonization in babies, providing potential intervention targets to prevent Crohn's disease development in high risk individuals.
common.study.values.location
participant.ui.study.affiliations-map.online-study.header-virtual
participant.ui.study.affiliations-map.online-study.text
common.study.values.methods
common.study.methods.has-drugs-no
common.study.methods.is-healthy-no
Diet-CD
CD patients will self-select into the intervention arm to follow the diet for 8-10 weeks during their third trimester of pregnancy.
participant.views.study.view.additional
participant.views.study.view.scientific-title
The MELODY Trial: Modulating Early Life Microbiome Through Dietary Intervention in Crohn's Disease
common.study.values.clinical-trial-id
NCT03850600
participant.views.study.view.id
en5mYd
