Racial Differences in Vasoconstriction
common.study.values.description
“The Effect of Endothelin and L-Arginine on Racial Differences in Vasoconstriction”
The goal of the study is to examine the possible mechanisms of impaired cutaneous microvascular function through local heating along with administration of vasoconstrictors.
common.study.values.location
participant.ui.study.affiliations-map.online-study.header-virtual
participant.ui.study.affiliations-map.online-study.text
common.study.values.methods
common.study.methods.has-drugs-yes
common.study.methods.is-healthy-no
Drug - BQ-788
This intervention is aimed at blocking endothelin type B receptors to assess racial differences during vasoconstriction. The infusion rate will be 2 µl/min
Drug - BQ-123
This intervention is aimed at blocking endothelin type A receptors to assess racial differences during vasoconstriction. The infusion rate will be 2 µl/min
Drug - L-Arginine
A substrate that is administered to increase endogenous nitric oxide production. The infusion rate will be 2 µl/min
Drug - NG Nitro L Arginine Methyl Ester
L-Name is a NOS inhibitor that is administered to each site to allow for the quantification of NO contribution to vasodilation. The infusion rate will be 2 µl/min
Drug - Sodium Nitroprusside
SNP will be perfused through each site to induce maximal vasodilation. The infusion rate will be 2 µl/min
Drug - Lactated Ringer's
Lactated Ringer will serve as the control site. The infusion rate will be 2 µl/min
participant.views.study.view.additional
participant.views.study.view.scientific-title
The Effect of Endothelin and L-Arginine on Racial Differences in Vasoconstriction
common.study.values.clinical-trial-id
NCT03679780
participant.views.study.view.id
erk2Ka
