Eligibility Details:
Inclusion Criteria:
- Resident in greater Seattle metropolitan area (King County), Pierce or Snohomish
Counties
- Healthy
- Able to perform all study requirements, including attendance at clinic visits and
capable of responding to questionnaires and clinic and exercise facility instructions
in English
- Willing to be randomized
- Capable of providing informed consent
Exclusion Criteria:
- Pregnant in past 3 months
- Lactating
- Premenopausal women: irregular menstrual periods for the previous 6 months; no use of
oral contraceptives for the previous 3 months, no use of hormone implants or
intrauterine device (IUD) for in the previous year, no use of other sex hormones
including testosterone or other androgens for the previous 3 months
- Postmenopausal women: no use of any sex hormones (estrogen, progesterone, testosterone
or other androgens, for the previous 3 months) of any type including oral, creams,
vaginal creams or inserts, patches, implants
- Current use of any tobacco products including smoking, vaping, chew, nicotine patches
- History of diabetes mellitus, or fasting glucose fingerstick >= 126 mg/dL
- Taking any medications to treat high blood sugar such as metformin
- Personal history of invasive or in situ breast cancer
- Personal history of cancer other than breast: exceptions are nonâ€melanoma skin cancer
and cervical neoplasia (CIN)
- >= 2 alcoholic drinks/day
- Contraindications to exercise
- Abnormalities on screening physical that contraindicate participation
- Contraindications for entry into a research exercise program: recent (within 6 months)
myocardial infarction, pulmonary edema, myocarditis, pericarditis, unstable angina,
pulmonary embolism, deep vein thrombosis, uncontrolled hypertension (systolic > 200,
diastolic > 100), orthostatic hypotension, moderate/severe aortic stenosis,
uncontrolled arrhythmia, uncontrolled congestive heart failure, left bundle branch
block, history of cardiac arrest or stroke
- Frequent marijuana use (> 1 per month)
- Alcohol or drug abuse, significant mental illness (as assessed by study staff
impression)
- History of clotting disorders (muscleâ€biopsy sub study)
- Unable or unwilling to stop aspirin or nonsteroidal antiinflammatory drugs (NSAIDs)
for 48 hours before and after the procedure (muscleâ€biopsy sub study)
- Allergy to anesthetics or local anesthetics (muscleâ€biopsy sub study)
- Long term use of warfarin or similar medications (muscleâ€biopsy sub study)