Neuropeptides in Human Reproduction

Neuropeptides in Human Reproduction

The investigators are seeking healthy volunteers and volunteers with reproductive disorders for the study of the role of dynorphin in the reproductive system. Dynorphin is a naturally occurring opioid hormone that is blocked by naloxone. We hypothesize that naloxone, by blocking dynorphin, will stimulate production of GnRH and kisspeptin, 2 other naturally occurring reproductive hormones.

Pharmaceutical medication involved
Patients and healthy individuals accepted

Drug - Kisspeptin 112-121

Subjects will receive up to 10 intravenous doses of kisspeptin 112-121

Drug - Naloxone

Subjects will receive one intravenous dose of naloxone followed by an intravenous infusion of naloxone.

Drug - Gonadotropin Releasing Hormone (GnRH)

Subjects will receive up to 10 doses of intravenous Gonadotropin Releasing Hormone (GnRH)

Neuropeptides in Human Reproduction