common.study.topics.clinical

Neuropeptides in Human Reproduction

common.study.values.description

Neuropeptides in Human Reproduction

The investigators are seeking healthy volunteers and volunteers with reproductive disorders for the study of the role of dynorphin in the reproductive system. Dynorphin is a naturally occurring opioid hormone that is blocked by naloxone. We hypothesize that naloxone, by blocking dynorphin, will stimulate production of GnRH and kisspeptin, 2 other naturally occurring reproductive hormones.

common.study.values.location

participant.ui.study.affiliations-map.online-study.header-virtual

participant.ui.study.affiliations-map.online-study.text

participant.ui.study.affiliations-map.legend.locations participant.ui.study.affiliations-map.legend.selected

common.study.values.methods

Pharmaceutical medication involved common.study.methods.has-drugs-yes
Patients and healthy individuals accepted common.study.methods.is-healthy-no

Drug - Kisspeptin 112-121

Subjects will receive up to 10 intravenous doses of kisspeptin 112-121

Drug - Naloxone

Subjects will receive one intravenous dose of naloxone followed by an intravenous infusion of naloxone.

Drug - Gonadotropin Releasing Hormone (GnRH)

Subjects will receive up to 10 doses of intravenous Gonadotropin Releasing Hormone (GnRH)

participant.views.study.view.additional

participant.views.study.view.scientific-title

Neuropeptides in Human Reproduction

common.study.values.clinical-trial-id

NCT01952782

participant.views.study.view.id

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