Neuropeptides in Human Reproduction
common.study.values.description
“Neuropeptides in Human Reproduction”
The investigators are seeking healthy volunteers and volunteers with reproductive disorders for the study of the role of dynorphin in the reproductive system. Dynorphin is a naturally occurring opioid hormone that is blocked by naloxone. We hypothesize that naloxone, by blocking dynorphin, will stimulate production of GnRH and kisspeptin, 2 other naturally occurring reproductive hormones.
common.study.values.location
participant.ui.study.affiliations-map.online-study.header-virtual
participant.ui.study.affiliations-map.online-study.text
common.study.values.methods
common.study.methods.has-drugs-yes
common.study.methods.is-healthy-no
Drug - Kisspeptin 112-121
Subjects will receive up to 10 intravenous doses of kisspeptin 112-121
Drug - Naloxone
Subjects will receive one intravenous dose of naloxone followed by an intravenous infusion of naloxone.
Drug - Gonadotropin Releasing Hormone (GnRH)
Subjects will receive up to 10 doses of intravenous Gonadotropin Releasing Hormone (GnRH)
participant.views.study.view.additional
participant.views.study.view.scientific-title
Neuropeptides in Human Reproduction
common.study.values.clinical-trial-id
NCT01952782
participant.views.study.view.id
lej0Wb
