“Gene Expression and Biomarker Profiling of Keloid Skin”
This study aims to examine both the genetic profile and the biomarkers implicated in keloid scar formation. Hypothesis: 1. Differences in the genetic profiles of lesional and non-lesional skin contribute a given population's propensity to develop keloids 2. Differences in biomolecules expressed in subjects with and without keloids can help predict keloid occurrence and severity 3. Biomarker analysis will provide useful insights for future targeted therapies for keloid scars
Procedure - Biopsy and/or triamcinolone injection
Subjects will have their blood drawn during the first study visit. Subsequently, a punch biopsy and/or triamcinolone injection will be given based on group timeline.
Procedure - Excisional Biopsy
Complete excision of an earlobe keloid will be taken.
Gene Expression and Biomarker Profiling of Keloid Skin