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Meal Related Interoceptive Dysfunction in Anorexia Nervosa

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Neural Basis of Meal Related Interoceptive Dysfunction in Anorexia Nervosa

This study aims to identify the brain regions responsible for encoding cardiorespiratory 'interoceptive' sensations and determine whether they are dysfunctional in individuals affected by eating disorders, anxiety, depression, or brain injury. By evaluating the same interoceptive sensations across different human illnesses, the investigators hope to provide convergent evidence resulting in identification of core underlying neural processes, and to discern relative contributions in each condition.

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participant.ui.study.affiliations-map.online-study.header-virtual

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Pharmaceutical medication involved common.study.methods.has-drugs-yes
Patients and healthy individuals accepted common.study.methods.is-healthy-no

Drug - Isoproterenol

Intravenous infusions of isoproterenol, delivered in a randomized double blinded order, in each participant from each group. Participants will rate the experience of heartbeat and breathing sensations as well as anxiety induced by the infusion.

Drug - Normal saline

Intravenous infusions of normal saline, delivered in a randomized double blinded order, in each participant from each group. Participants will rate the experience of heartbeat and breathing sensations as well as anxiety induced by the infusion.

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participant.views.study.view.scientific-title

Neural Basis of Meal Related Interoceptive Dysfunction in Anorexia Nervosa

common.study.values.clinical-trial-id

NCT02615119

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mbkBKa