common.study.topics.clinical

Regulation of Insulin Secretion

common.study.values.description

Regulation of Insulin Secretion by the GLP-1 Receptor

The purpose of this study is to determine the role of basal GLP-1 action on the -cell response to insulin resistance. Healthy subjects will have fasting GLP-1 action determined with GLP-1r blockade before and after induction of experimental insulin resistance. The investigators hypothesize that fasting GLP-1 action will increase to compensate for experimental insulin resistance.

common.study.values.location

participant.ui.study.affiliations-map.online-study.header-virtual

participant.ui.study.affiliations-map.online-study.text

participant.ui.study.affiliations-map.legend.locations participant.ui.study.affiliations-map.legend.selected

common.study.values.methods

Pharmaceutical medication involved common.study.methods.has-drugs-yes
Patients and healthy individuals accepted common.study.methods.is-healthy-no

Drug - Exendin (9-39)

Upon establishing a hyperglycemic clamp (target blood glucose at basal +3 mM) Exendin (9-39) will be infused.

Drug - Dexamethasone

Between Visit-2 and Visit-3, Dexamethasone (4 mg tablet) once daily for 5-7 days.

Hyperglycemic Clamp

A variable infusion of 20% dextrose will begin to clamp the blood glucose at basal +3 mM.

participant.views.study.view.additional

participant.views.study.view.scientific-title

Regulation of Insulin Secretion by the GLP-1 Receptor

common.study.values.clinical-trial-id

NCT02844907

participant.views.study.view.id

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