Regulation of Insulin Secretion

Regulation of Insulin Secretion by the GLP-1 Receptor

The purpose of this study is to determine the role of basal GLP-1 action on the -cell response to insulin resistance. Healthy subjects will have fasting GLP-1 action determined with GLP-1r blockade before and after induction of experimental insulin resistance. The investigators hypothesize that fasting GLP-1 action will increase to compensate for experimental insulin resistance.

Pharmaceutical medication involved
Patients and healthy individuals accepted

Drug - Exendin (9-39)

Upon establishing a hyperglycemic clamp (target blood glucose at basal +3 mM) Exendin (9-39) will be infused.

Drug - Dexamethasone

Between Visit-2 and Visit-3, Dexamethasone (4 mg tablet) once daily for 5-7 days.

Hyperglycemic Clamp

A variable infusion of 20% dextrose will begin to clamp the blood glucose at basal +3 mM.

Regulation of Insulin Secretion by the GLP-1 Receptor