Regulation of Insulin Secretion
common.study.values.description
“Regulation of Insulin Secretion by the GLP-1 Receptor”
The purpose of this study is to determine the role of basal GLP-1 action on the -cell response to insulin resistance. Healthy subjects will have fasting GLP-1 action determined with GLP-1r blockade before and after induction of experimental insulin resistance. The investigators hypothesize that fasting GLP-1 action will increase to compensate for experimental insulin resistance.
common.study.values.location
participant.ui.study.affiliations-map.online-study.header-virtual
participant.ui.study.affiliations-map.online-study.text
common.study.values.methods
common.study.methods.has-drugs-yes
common.study.methods.is-healthy-no
Drug - Exendin (9-39)
Upon establishing a hyperglycemic clamp (target blood glucose at basal +3 mM) Exendin (9-39) will be infused.
Drug - Dexamethasone
Between Visit-2 and Visit-3, Dexamethasone (4 mg tablet) once daily for 5-7 days.
Hyperglycemic Clamp
A variable infusion of 20% dextrose will begin to clamp the blood glucose at basal +3 mM.
participant.views.study.view.additional
participant.views.study.view.scientific-title
Regulation of Insulin Secretion by the GLP-1 Receptor
common.study.values.clinical-trial-id
NCT02844907
participant.views.study.view.id
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