Postoperative Nausea and Emesis in Gastrectomy
common.study.values.description
“Designing Optimal Prevention and Management of Postoperative Nausea and Emesis for Patients Undergoing Laparoscopic Sleeve Gastrectomy”
Bariatric surgery remains the most effective therapy for obesity. Postoperative nausea and vomiting (PONV) are commonly reported following bariatric surgery. The proposed study focuses on the most common bariatric procedure performed, laparoscopic sleeve gastrectomy (LSG), and aims to assess the effect of a post-operative nausea and vomiting-specific intervention. The investigators hypothesize that the intervention group will experience a reduction of nausea-related prolonged hospital stay and significantly improve patient-reported quality of recovery from surgery and quality of life.
common.study.values.location
participant.ui.study.affiliations-map.online-study.header-virtual
participant.ui.study.affiliations-map.online-study.text
common.study.values.methods
common.study.methods.has-drugs-yes
common.study.methods.is-healthy-no
Drug - Aprepitant 80Mg Oral Capsule
aprepitant 80 mg orally one hour prior to scheduled surgery
Drug - scopolamine transdermal
scopolamine transdermal patch one hour prior to scheduled surgery
Procedure - Total intravenous anesthesia
Maintenance of anesthesia without the use of inhaled anesthetics.
Drug - Dexamethasone
Dexamethasone 8 mg intraoperatively
Drug - Ondansetron
Ondansetron 4 mg intraoperatively. Ondansetron will be given twice. Once intraoperatively and then post- operatively.
Drug - Reglan
Postoperatively scheduled Reglan
Drug - Ondansetron
Postoperatively scheduled ondansetron
Drug - Compazine
Postoperatively as needed compazine for breakthrough PONV
Drug - Sugammadex
Reversal with sugammadex
Drug - Propofol
Intravenous anesthesuia will be maintained through IV propofol
Drug - dexmedetomidine
maintainance of anesthesia in the intervention arm
Drug - Fentanyl
intermittent bolus dosing of fentanyl will be used after induction for anesthesia maintenance
Drug - Sevoflurane
inhalational anesthesia
Drug - Desflurane
inhalational anesthesia
participant.views.study.view.additional
participant.views.study.view.scientific-title
Designing Optimal Prevention and Management of Postoperative Nausea and Emesis for Patients Undergoing Laparoscopic Sleeve Gastrectomy
common.study.values.clinical-trial-id
NCT03435003
participant.views.study.view.id
mepxme
