Prevention of Infections in Cardiac Surgery

Prevention of Infections in Cardiac Surgery (PICS) Prevena Study

This vanguard study will be conducted at two study sites in Canada. It is a cluster randomized trial to test a combination of two antibiotics for antibiotic prophylaxis as compared to routine prophylaxis with one single antibiotic, and to test a negative-pressure wound management system (Prevena) versus standard wound dressing to reduce chest wound infections.

Pharmaceutical medication involved
Recruiting patients only

Device - Prevena

Negative-Pressure Wound Management System

Drug - Cefazolin


Drug - Vancomycin


standard wound dressing

Any non-negative pressure wound dressing that is routinely used at study sites will be considered standard of care in the control arms.

A Cluster-randomized Factorial Crossover Trial, Comparing Antibiotic Mono-prophylaxis With Cefazolin vs. Dual-prophylaxis With Cefazolin Plus Vancomycin and Conventional Wound Dressing vs. Prevena Negative-pressure Wound Management