Intrathecal Morphine Microdose Method Sensory Changes

Intrathecal Morphine Microdose Method Sensory Changes

Following the retrospective study on the effectiveness of the microdose method of intrathecal morphine therapy, the investigators are interested in measuring the sensory changes at 4 time points during the microdose method. The microdose method involves weaning the patient off oral opioids and maintaining an opioid-free period prior to initiating a very low opioid dose in intrathecal therapy. The microdose method is a standard of care. The study involves measuring sensory changes to hot, cold, and pressure. Data collection will be performed at regularly scheduled clinic visits, examining range of doses, pain scores,dose escalations, quantifiable psychosocial factors ( not captured in previous retrospective study), and changes in sensory thresholds.

No pharmaceutical medication involved
Patients and healthy individuals accepted

Behavioral - Quantitative Sensory Tests

Three testing modalities will be utilized for this study: Hot threshold test: The hot threshold method we will be utilizing has been described in the literature with good reproducibility and reliability. We will be using a similar system and have reproduced the program using a non-invasive device. Cold threshold test: the same non-invasive device will be used to test cold detection and pain threshold levels. This method is previously described. Pressure threshold: Mechanical testing (pressure pa more on

Behavioral - surveys

surveys including anxiety, depression, pain behavior, fatigue, pain interference, physical function, sleep disturbance, self-efficacy, satisfaction roles

Intrathecal Morphine Microdose Method Sensory Changes: A Pilot Study