Eligibility Details:
1. Healthy young adults Eligible subjects are males and females aged 18-30 years with no
significant health issues
Inclusion Criteria:
A subject must meet the following criteria to be eligible for inclusion in the study:
- Men and women aged 18- 30 years, with no significant health issues or conditions
that, in the investigator's opinion, would limit the subject's ability to
complete the study activities or that would impact the capability to get an
accurate measurement of study endpoints.
- Body mass index (BMI) between 17 and 30 kg/m2.
- Willing to undergo multiple MRI sessions.
- Willing and able to return for all visits and complete all study-related
activities.
- Able to read, understand, and complete study-related questionnaires
- Able to read and understand, and willing to sign the informed consent form (ICF).
Exclusion criteria:
A subject who meets any of the following criteria will be excluded from the study:
- Having body dimensions that exceed the MRI or exercise equipment limits.
- Unable to undergo MRI (e. g. body containing any metallic medical devices or
equipment, including heart pacemakers, metal prostheses, implants or surgical
clips, any prior injury from shrapnel or grinding metal, exposure to metallic
dusts, metallic shavings or having tattoos containing metallic dyes)
- Abnormal or uncontrolled blood pressure at the screening visit defined as BP >
180/100 mmHg.
- Positive pregnancy test.
- Having a personal history of the following neurological disorders: Alzheimers,
Amyotrophic Lateral Sclerosis, Multiple Sclerosis, Parkinsons, Stroke
- Having a personal history of the following cardiorespiratory disorders:
Congestive heart failure, Heart attack in past 24 months
- Having a personal history of the following musculoskeletal disorders: Rheumatoid
Arthritis, pathologic fractures of the spine, avascular necrosis or
osteonecrosis, severe osteoarthritis. Including a history of spine surgery or a
hip arthroplasty.
- Having neurological symptoms (ie. burning, numbness, tingling sensations into the
legs), muscle weakness associated with neural dysfunction (i.e. foot drop), or
episodes of incontinence of bowel or bladder.
- Having active cancer
- Blindness
- Having used opioids or muscle relaxants within 30 days prior to study enrollment.
- Reports being pregnant, lactating, or that they anticipate becoming pregnant in
the next 3-months. If a woman becomes pregnant while on study protocol they will
be withdrawn from the study.
- Reports unexplained weight loss over the past month (greater than 10 lbs).
- Failure to provide informed consent.
2. Young adults with chronic low back pain (CLBP) Eligible subjects are males and females
aged 18- 30 years with no significant health issues except self report of CLBP
Inclusion Criteria:
A subject must meet the following criteria to be eligible for inclusion in the study:
- Men and women aged 18- 30 years, with no significant health issues or conditions
that, in the investigator's opinion, would limit the subject's ability to
complete the study activities or that would impact the capability to get an
accurate measurement of study endpoints.
- Body mass index (BMI) between 17 and 30 kg/m2.
- Willing to undergo multiple MRI sessions.
- Willing and able to return for all visits and complete all study-related
activities.
- Able to read, understand, and complete study-related questionnaires.
- Able to read and understand, and willing to sign the informed consent form (ICF).
- Reports average pain intensity (assessed using the Numerical Pain Rating (NPRS)
scale) over the past week greater than or equal to 3 on a 0-10 numerical pain
scale.
- Oswestry Low Back Pain Disability Questionnaire score > 20% (moderate disability
and above).
- Answers yes to the following questions:
Have you had low back pain constantly or on most days for the last three months? Has
your back pain caused you to seek care or consultation from a health care provider?
Exclusion criteria:
A subject who meets any of the following criteria will be excluded from the study:
- Having body dimensions that exceed the MRI or exercise equipment limits.
- Unable to undergo MRI (e. g. body containing any metallic medical devices or
equipment, including heart pacemakers, metal prostheses, implants or surgical
clips, any prior injury from shrapnel or grinding metal, exposure to metallic
dusts, metallic shavings or having tattoos containing metallic dyes)
- Abnormal or uncontrolled blood pressure at the screening visit defined as BP >
180/100 mmHg.
- Positive pregnancy test.
- Having a personal history of the following neurological disorders: Alzheimers,
Amyotrophic Lateral Sclerosis, Multiple Sclerosis, Parkinsons, Stroke
- Having a personal history of the following cardiorespiratory disorders:
Congestive heart failure, Heart attack in past 24 months
- Having a personal history of the following musculoskeletal disorders: Rheumatoid
Arthritis, pathologic fractures of the spine, avascular necrosis or
osteonecrosis, severe osteoarthritis. Including a history of spine surgery or a
hip arthroplasty
- Having neurological symptoms (ie. burning, numbness, tingling sensations into the
legs), muscle weakness associated with neural dysfunction (i.e. foot drop), or
episodes of incontinence of bowel or bladder
- Having active cancer
- Blindness
- Having used opioids or muscle relaxants within 30 days prior to study enrollment.
- Reports being pregnant, lactating, or that they anticipate becoming pregnant in
the next 3-months. If a woman becomes pregnant while on study protocol they will
be withdrawn from the study.
- Reports unexplained weight loss over the past month (greater than 10 lbs).
- Reports having pending litigation related to an episode of LBP or are receiving
any type of disability services related to low back pain.
- Reports having received any manual therapy intervention applied to the spine 30
days prior to first study intervention.
- Reports current drug or alcohol use or dependence that, in the opinion of the
PIs, would interfere with adherence to study requirements.
- Failure to provide informed consent.
3. Healthy middle-aged and older adults Eligible subjects are males and females aged 55+
years with no significant health issues
Inclusion Criteria:
A subject must meet the following criteria to be eligible for inclusion in the study:
- Men and women over 55 years of age, with no significant health issues or
conditions that, in the investigator's opinion, would limit the subject's ability
to complete the study activities or that would impact the capability to get an
accurate measurement of study endpoints.
- Body mass index (BMI) between 17 and 30 kg/m2.
- Willing to undergo multiple MRI sessions.
- Willing and able to return for all visits and complete all study-related
activities.
- Able to read, understand, and complete study-related questionnaires
- Able to read and understand, and willing to sign the informed consent form (ICF).
Exclusion criteria:
A subject who meets any of the following criteria will be excluded from the study:
- Having body dimensions that exceed the MRI or exercise equipment limits.
- Unable to undergo MRI (e. g. body containing any metallic medical devices or
equipment, including heart pacemakers, metal prostheses, implants or surgical
clips, any prior injury from shrapnel or grinding metal, exposure to metallic
dusts, metallic shavings or having tattoos containing metallic dyes)
- Abnormal or uncontrolled blood pressure at the screening visit defined as BP >
180/100 mmHg.
- Positive pregnancy test.
- Having a personal history of the following neurological disorders: Alzheimers,
Amyotrophic Lateral Sclerosis, Multiple Sclerosis, Parkinsons, Stroke
- Having a personal history of the following cardiorespiratory disorders:
Congestive heart failure, Heart attack in past 24 months
- Having a personal history of the following musculoskeletal disorders: Rheumatoid
Arthritis, pathologic fractures of the spine, avascular necrosis or
osteonecrosis, severe osteoarthritis. Including a history of spine surgery or a
hip arthroplasty
- Having neurological symptoms (ie. burning, numbness, tingling sensations into the
legs), muscle weakness associated with neural dysfunction (i.e. foot drop), or
episodes of incontinence of bowel or bladder
- Having active cancer
- Blindness
- Having used opioids or muscle relaxants within 30 days prior to study enrollment.
- Reports being pregnant, lactating, or that they anticipate becoming pregnant in
the next 3-months. If a woman becomes pregnant while on study protocol they will
be withdrawn from the study.
- Reports unexplained weight loss over the past month (greater than 10 lbs).
- Failure to provide informed consent.
4. Healthy middle-aged and older adults with high levels of trunk muscle control (ie.
individuals with expertise in the Pilates Method of exercise)
Eligible subjects are males and females aged 55+ years with no significant health issues
Inclusion Criteria:
A subject must meet the following criteria to be eligible for inclusion in the study:
- Men and women over 55 years of age, with no significant health issues or conditions
that, in the investigator's opinion, would limit the subject's ability to complete the
study activities or that would impact the capability to get an accurate measurement of
study endpoints.
- Reports being trained in the Pilates method exercises and has been performing these
exercises 2 times per week for the past one year.
- Body mass index (BMI) between 17 and 30 kg/m2.
- Willing to undergo multiple MRI sessions.
- Willing and able to return for all visits and complete all study-related activities.
- Able to read, understand, and complete study-related questionnaires
- Able to read and understand, and willing to sign the informed consent form (ICF).
Exclusion criteria:
A subject who meets any of the following criteria will be excluded from the study:
- Having body dimensions that exceed the MRI or exercise equipment limits.
- Unable to undergo MRI (e. g. body containing any metallic medical devices or
equipment, including heart pacemakers, metal prostheses, implants or surgical clips,
any prior injury from shrapnel or grinding metal, exposure to metallic dusts, metallic
shavings or having tattoos containing metallic dyes)
- Abnormal or uncontrolled blood pressure at the screening visit defined as BP > 180/100
mmHg.
- Positive pregnancy test.
- Having a personal history of the following neurological disorders: Alzheimers,
Amyotrophic Lateral Sclerosis, Multiple Sclerosis, Parkinsons, Stroke
- Having a personal history of the following cardiorespiratory disorders: Congestive
heart failure, Heart attack in past 24 months
- Having a personal history of the following musculoskeletal disorders: Rheumatoid
Arthritis, pathologic fractures of the spine, avascular necrosis or osteonecrosis,
severe osteoarthritis. Including a history of spine surgery or a hip arthroplasty
- Having neurological symptoms (ie. burning, numbness, tingling sensations into the
legs), muscle weakness associated with neural dysfunction (i.e. foot drop), or
episodes of incontinence of bowel or bladderHaving active cancer
- Blindness
- Having used opioids or muscle relaxants within 30 days prior to study enrollment.
- Reports being pregnant, lactating, or that they anticipate becoming pregnant in the
next 3-months. If a woman becomes pregnant while on study protocol they will be
withdrawn from the study.
- Reports unexplained weight loss over the past month (greater than 10 lbs).
- Failure to provide informed consent.
common.study.methods.has-drugs-no
common.study.methods.is-healthy-no
