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The Irisin and Metabolic Exercise Training Study

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The Irisin and Metabolic Exercise Training Study

It has been established that greater amounts of vigorous intensity physical activity lead to improved health outcomes. Interestingly, the response of biologically active substances, called myokines, differs according to exercise intensity. As such, the current study aims to compare the difference in the response to irisin according to different exercise intensities in both normal weight subjects and individuals living with obesity. This study will compare continuous moderate intensity physical activity to high intensity physical activity against a control condition. Furthermore, this study will determine whether differences in exercise intensity are associated with better insulin sensitivity.

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No pharmaceutical medication involved common.study.methods.has-drugs-no
Patients and healthy individuals accepted common.study.methods.is-healthy-no

Behavioral - High Intensity Interval Aerobic Exercise (HIIT)

Cycling at 50-55% heart rate reserve for 5 minutes followed by 2 minutes of cycling at 85-90% heart rate reserve consecutively for a total of 35 minutes. Blood draws will occur at 6 different time points during exercise (0min, 7min, 14min, 21min, 28min, 35min).

Behavioral - Continuous Moderate Aerobic Exercise (MOD)

35 minutes of cycling at 50-55% heart rate reserve. Blood draws will occur at 6 different time points during exercise (0min, 7min, 14min, 21min, 28min, 35min).

Behavioral - Control Sitting Condition (C)

Blood draws matched for exercise time will be taken while participant remains seated for 35 minutes (0min, 7min, 14min, 21min, 28min, 35min).

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The Irisin and Metabolic Exercise Training Study

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NCT03514238

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nelz1b