Bone Health After Bariatric Surgery in Type 2 Diabetes

Background: Bone fragility is a complication of type 2 diabetes. Diabetes treatments may ameliorate or deteriorate bone fragility in this population. Bariatric surgery is gaining in popularity in people with type 2 diabetes and may impact bone health. Objectives: To evaluate the impact of the 2 most popular bariatric procedures worldwide (SG, RYGB) on vBMD by QCT in patients with type 2 diabetes; Secondary aims: (1) to identify the determinants of vBMD after bariatric surgery in patients with type 2; (2) to compare vBMD and its potential determinants after bariatric surgery with controls with a normal BMI and normoglycemia ; (3) to compare changes in vBMD and its potential determinants after SG (the most popular bariatric procedure) with obese controls without diabetes. Exploratory aims: (1) to evaluate the prevalence and incidence at one year of falls as well as vertebral and non-vertebral fractures after SG and RYGB; (2) to evaluate bone microarchitecture and metabolism by iliac crest bone biopsy in patients with obesity, with or without type 2 diabetes, before SG.