Eligibility Details:
Inclusion Criteria:
- Subjects will be healthy men and women between 18 - 50 years of age who identify as
African American or Black, Asian, Hispanic or Latino, American Indian/Alaska Native,
Native Hawaiian/Other Pacific Islander, Caucasian/White, bi-/multiracial.
Exclusion Criteria:
- Unable to give consent
- Severe general allergies requiring chronic treatment with steroids or antihistamines
- Previous adverse reaction to microneedle insertion
- Known allergy or adverse reaction to medical tape, adhesive, or aloe vera
- Anyone with inflammatory diseases of the skin or diseases that alter immune function
- Anyone taking any medications that impair the immune system will be excluded
(contraceptives, vitamins, and topical products on the face will be allowed)
- Anyone with current malignancy or history of malignancy present at the treatment site
(upper arm)
- Anyone with any of the following present at the treatment site (upper arm): eczema or
scaling, inflammation, erythema, edema, blisters
- Anyone with uncontrolled mental illness that would, in the opinion of the physician,
affect their ability to understand or reliably participate in the study
- Anyone taking medications in the following therapeutic classes will be excluded:
HMGCoA reductase inhibitors ("statins"), oral or topical steroids, oral antibiotics,
topical antibiotics at the local treatment site, topical antihistamines at the local
treatment site, beta-blockers, and systemic or topical NSAIDS/analgesics
- Anyone who is pregnant or nursing
- Anyone with any condition that would, in the opinion of the PI or physician, place the
subject at an unacceptable risk of injury or render the subject unable to meet the
requirements of the protocol