Eligibility Details:
- Cardiovascular Disease Eligibility Criteria
INCLUSION CRITERIA:
- Females and males 18 years of age or older
- Diagnosis of clinical CAD (including abnormal EKG with a prior infarction pattern,
abnormal echo consistent with a wall motion abnormality or a referral note from
cardiologist with diagnosis of CAD)
- CAD that is currently stable (defined by no change in medications for blood pressure,
angina or diuretic therapy or in no new CV symptoms over the past month in a patient
who has had a primary cardiac event or an abnormal EKG with confirmed wall motion
abnormality)
- CAD which may be associated with chronic stable angina (defined by a clinical syndrome
characterized by discomfort in the chest, jaw, shoulder, back, or arm by a physician).
EXCLUSION CRITERIA:
- For imaging studies, pregnant women.
- For imaging studies, lactating women
- For optional adipose biopsy, any subject with known bleeding disorder, current fever
or on anti-coagulation.
- For optional MRI, inability to participate due to metal within body, claustrophobia,
or anything else that prohibits undergoing a MRI scan
- Any solid organ or liquid tumor within the past five years, with the exception of
nonmelanomatous skin cancer,
- Active infectious diseases within 3 months requiring antibiotics, collagen vascular
diseases such as RA, psoriasis and mixed connective tissue diseases and
immune-mediated lung diseases (e.g. IPF, BOOP)
- A BMI >40 kg/m(2) due to PET MRI restrictions
- Subjects with severe renal excretory dysfunction, estimated glomerular filtration rate
< 30 mL/min/1.73m(2) body surface area according to the Modification of Diet in Renal
Disease criteria, will not receive the cardiac CT angiography, or gadolinium contrast
agent during the PET/MRI.
- Subjects with second -or third-degree AV block or sinus node dysfunction will not
receive the 13N-ammonia PET/CT imaging unless these patients have a functioning
artificial pacemaker.
- Subjects with any signs or symptoms of acute coronary syndrome, including vasoreactive
hypertension with blood pressure exceeding 180/100, any concerning ST segment changes
on ECG, or acute chest pain, will not receive the 13N-ammonia PET/CT imaging.
Diabetes Mellitus Eligibility Criteria
INCLUSION CRITERIA:
- Females and males 18 years of age or older
- Diagnosis of type 2 diabetes mellitus (DM), currently stable as defined by no change
in antidiabetic medications over the past month and fasting glucose <200
EXCLUSION CRITERIA:
- For imaging studies, pregnant women
- For imaging studies, lactating women
- For optional adipose biopsy, any subject with known bleeding disorder, current fever
or on anti-coagulation.
- For optional MRI, inability to participate due to metal within body, claustrophobia,
or anything else that prohibits undergoing a MRI scan
- Any solid organ or liquid tumor within the past five years, with the exception of
nonmelanomatous skin cancer,
- Active infectious diseases within 3 months requiring antibiotics, collagen vascular
diseases such as RA, psoriasis and mixed connective tissue diseases and
immune-mediated lung diseases (e.g. IPF, BOOP)
- A BMI >40 kg/m(2) due to PET MRI restrictions
- Subjects with severe renal excretory dysfunction, estimated glomerular filtration rate
< 30 mL/min/1.73m(2) body surface area according to the Modification of Diet in Renal
Disease criteria, will not receive the cardiac CT angiography, or gadolinium contrast
agent during the PET/MRI.
- Subjects with second -or third-degree AV block or sinus node dysfunction will not
receive the 13N-ammonia PET/CT imaging unless these patients have a functioning
artificial pacemaker.
- Subjects with any signs or symptoms of acute coronary syndrome, including vasoreactive
hypertension with blood pressure exceeding 180/100, any concerning ST segment changes
on ECG, or acute chest pain, will not receive the 13N-ammonia PET/CT imaging.
Healthy Volunteers:
INCLUSION CRITERIA:
-Females and males 18 years of age or older without any clinical diagnosis of a chronic
health condition that is knownto accelerate vascular disease beyond traditional risk
factors including lung disease or active infection
EXCLUSION CRITERIA:
- For imaging studies, pregnant women
- For imaging studies, lactating women
- For optional MRI, inability to participate due to in optional MRI metal within body,
claustrophobia, or anything else that prohibits undergoing a MRI scan
- Any solid organ or liquid tumor within the past five years, with the exception of non
melanomatous skin cancer,
- Active infectious diseases within 3 months requiring antibiotics, collagen vascular
diseases such as RA, psoriasis and mixed connective tissue diseases and
immune-mediated lung diseases (e.g. IPF, BOOP)
- Clinical diagnosis of diabetes or cardiovascular disease
- Fasting glucose >125,
- LDL>200,
- LFT s 3 times normal limit,
- eGFR<60,
- Subjects with severe renal excretory dysfunction will not receive the cardiac CT
angiography, or gadolinium contrast agent during the PET/MRI.
- A BMI >40 kg/m(2) due to PET MRI restrictions.
- Subjects with second -or third-degree AV block or sinus node dysfunction will not
receive the 13N-ammonia PET/CT imaging unless these patients have a functioning
artificial pacemaker.
- Subjects with any signs or symptoms of acute coronary syndrome, including vasoreactive
hypertension with blood pressure exceeding 180/100, any concerning ST segment changes
on ECG, or acute chest pain, will not receive the 13N-ammonia PET/CT imaging.
common.study.methods.has-drugs-no
common.study.methods.is-healthy-no
