PICS: Subtitle Cardiac Dysfunction in Older Sepsis Survivors
“PICS: Subtitle Cardiac Dysfunction in Older Sepsis Survivors”
The purpose of this study is to define the natural history and causes of chronic critical illness (CCI) in surgical intensive care patients who have had sepsis. The investigator also wants to define the long-term physical and cognitive outcomes of this disease. The investigator will be looking at many clinical variables to try to define CCI.
Blood will be collected from patient at baseline, day 1, day 4, day 7 and weekly until week 6 as long as the patient is still hospitalized. Blood will also be collected at the one year appointment.
Urine will be collected from patient at baseline, day 1, day 4, day 7 and weekly until week 6 as long as the patient is still hospitalized. Urine will also be collected at the one year appointment.
The bioimpedance analysis will be performed at baseline, day 14 or discharge from hospitalization, month 3, month 6, and month 12.
Cognitive Function Tests
Cognitive function tests will be administered at 3, 6 and 12 months.
Quality-of-life questionnaires will be administered at baseline, 3, 6 and 12 months.
Physical Function Tests
Physical function tests will be administered at baseline, day 14 or discharge from hospital 3, 6 and 12 months.
The healthy volunteer participants will donate a blood sample. These controls will allow the investigators to determine if the values obtained are accurate, reliable, and repeatable.
Persistent Inflammation, Immunosuppression and Catabolism Syndrome (PICS): A New Horizon for Surgical Critical Care Subtitle: Cardiac Dysfunction in Older Sepsis Survivors