common.study.topics.clinical

Brain and Gut Plasticity in Mild TBI

common.study.values.description

Brain and Gut Plasticity in Mild TBI Following Growth Hormone Therapy

Patients with a history of mild traumatic brain injury (mTBI) and abnormal growth hormone secretion, as measured by glucagon stimulation test, will be treated with replacement growth hormone therapy for a period of 6 months. Testing of cognition, exercise, fatigue, brain activation and morphology, body composition and measurements of quality of life will be performed before and after the treatment period. Fecal sampling for characterization of the GI microbiome will occur monthly over the treatment period. Each mTBI subject will be required to enroll with an eligible control from their household that will also provide fecal samples monthly during the treatment period of their mTBI partner. GI microbiomes will be compared between mTBI patients and their household controls at baseline as well as over the treatment period.

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participant.ui.study.affiliations-map.online-study.header-virtual

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Pharmaceutical medication involved common.study.methods.has-drugs-yes
Patients and healthy individuals accepted common.study.methods.is-healthy-no

Drug - Somatropin

Genotropin given by injection

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Brain and Gut Plasticity in Mild TBI Following Growth Hormone Therapy

common.study.values.clinical-trial-id

NCT03554265

participant.views.study.view.id

vbmlGa