common.study.topics.clinical

A Prospective Study of Outcome After Therapy for Acromegaly

common.study.values.description

A Prospective Study of Outcome After Therapy for Acromegaly

The purpose of this study is to evaluate hormone values and other markers of disease activity in a cohort of patients with acromegaly at the time of diagnosis and then prospectively after surgical or other treatment. This study is designed to determine blood levels of growth hormone and related hormones and cardiovascular risk markers as well as signs and symptoms of the disease at diagnosis and how these parameters change over time after surgical or other therapy. The investigators will also obtain hormonal data in a group of 50 healthy subjects who will each be studied just once with an oral glucose tolerance test (OGTT). These data will provide a comparison group to the acromegaly subjects.

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Pharmaceutical medication involved common.study.methods.has-drugs-yes
Patients and healthy individuals accepted common.study.methods.is-healthy-no

Procedure - Surgery for acromegaly

(non-experimental) standard procedure

Drug - Medications for acromegaly

(non-experimental) standard procedure

Diagnostic Test - Total body magnetic resonance imaging

Subjects will undergo total body MRI with spectroscopy of the muscle and liver before and 3-6 months, 12 and 24 months after surgery or medical therapy for acromegaly.

Procedure - Adipose Tissue Biopsy

Subjects will undergo biopsy of subcutaneous adipose tissue before and 12 and 24 months after surgery or medical therapy for acromegaly.

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A Prospective Study of Outcome After Therapy for Acromegaly

common.study.values.clinical-trial-id

NCT01809808

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