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Adverse Metabolic Effects of Dietary Sugar

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Adverse Metabolic Effects of Dietary Sugar

It is not known whether consumption of excessive amounts of sugar can increase risk factors for cardiovascular disease or diabetes in the absence of increased food (caloric) intake and weight gain, nor whether the negative effects of sugar consumption are made worse when accompanied by weight gain. This study will investigate the effects of excess sugar when consumed with an energy-balanced diet that prevents weight gain, and the effects of excess sugar when consumed with a diet that can cause weight gain. The results will determine whether excess sugar consumption and excess caloric intake that lead to weight gain have independent and additive effects on risk factors for cardiovascular disease or diabetes, and will have the potential to influence dietary guidelines and public health policy.

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participant.ui.study.affiliations-map.online-study.text

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No pharmaceutical medication involved common.study.methods.has-drugs-no
Patients and healthy individuals accepted common.study.methods.is-healthy-no

high fructose corn syrup

High fructose corn syrup provided as 15% HFCS/85% water (weight/weight) fruit-flavored beverage

aspartame

Aspartame provided as 0.04% aspartame/99.96% water (weight/weight), fruit-flavored beverage

Energy-balanced diet

Provided in quantities that equal energy requirement. Formulated such that the overall macronutrient intake; including beverage; equal 45%/5% energy requirement at complex/simple carbohydrate, 35% energy requirement as fat, 15% energy requirement as protein.

Ad libitum diet

Provided in quantities that exceed energy requirement by approximately 25%. Formulated such that the overall macronutrient intake; including beverage; equals approximately 45%/5% energy requirement at complex/simple carbohydrate, 35% energy requirement as fat, 15% energy requirement as protein.

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Adverse Metabolic Effects of Dietary Sugar: Ad Libitum vs Energy-balanced Diets

common.study.values.clinical-trial-id

NCT02548767

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