Race, Natriuretic Peptides and Physiological Perturbations
common.study.values.description
“Race, Natriuretic Peptides and Physiological Perturbations”
The purpose of the study is to understand the origins of differential response to beta-blockers in African-Americans and may provide insight regarding racial differences in cardiovascular risk.
common.study.values.location
participant.ui.study.affiliations-map.online-study.header-virtual
participant.ui.study.affiliations-map.online-study.text
common.study.values.methods
common.study.methods.has-drugs-yes
common.study.methods.is-healthy-no
Exercise capacity VO2 max determination
Each participant's maximal oxygen capacity will be determined using a modified Bruce treadmill protocol.
Dietary Supplement - Standardized meals
Participants will consume the standardized study diet for 3 days provided by the clinical research unit's metabolic kitchen (at UAB).
Exercise challenge
Each participant will walk at 70 % of his/her VO2max for 20 minutes on treadmill.
Drug - Metoprolol Succinate ER
Each participant will receive metoprolol succinate starting at 50mg/day, titrated bi-weekly up to 200 mg/day for total duration of 6 weeks.
participant.views.study.view.additional
participant.views.study.view.scientific-title
Racial Differences in the Natriuretic Peptide Response to Exercise and Beta-blockers
common.study.values.clinical-trial-id
NCT03070184
participant.views.study.view.id
yb8NLe
