common.study.topics.clinical

Race, Natriuretic Peptides and Physiological Perturbations

common.study.values.description

Race, Natriuretic Peptides and Physiological Perturbations

The purpose of the study is to understand the origins of differential response to beta-blockers in African-Americans and may provide insight regarding racial differences in cardiovascular risk.

common.study.values.location

participant.ui.study.affiliations-map.online-study.header-virtual

participant.ui.study.affiliations-map.online-study.text

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common.study.values.methods

Pharmaceutical medication involved common.study.methods.has-drugs-yes
Patients and healthy individuals accepted common.study.methods.is-healthy-no

Exercise capacity VO2 max determination

Each participant's maximal oxygen capacity will be determined using a modified Bruce treadmill protocol.

Dietary Supplement - Standardized meals

Participants will consume the standardized study diet for 3 days provided by the clinical research unit's metabolic kitchen (at UAB).

Exercise challenge

Each participant will walk at 70 % of his/her VO2max for 20 minutes on treadmill.

Drug - Metoprolol Succinate ER

Each participant will receive metoprolol succinate starting at 50mg/day, titrated bi-weekly up to 200 mg/day for total duration of 6 weeks.

participant.views.study.view.additional

participant.views.study.view.scientific-title

Racial Differences in the Natriuretic Peptide Response to Exercise and Beta-blockers

common.study.values.clinical-trial-id

NCT03070184

participant.views.study.view.id

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