Race, Natriuretic Peptides and Physiological Perturbations

Race, Natriuretic Peptides and Physiological Perturbations

The purpose of the study is to understand the origins of differential response to beta-blockers in African-Americans and may provide insight regarding racial differences in cardiovascular risk.

Pharmaceutical medication involved
Patients and healthy individuals accepted

Exercise capacity VO2 max determination

Each participant's maximal oxygen capacity will be determined using a modified Bruce treadmill protocol.

Dietary Supplement - Standardized meals

Participants will consume the standardized study diet for 3 days provided by the clinical research unit's metabolic kitchen (at UAB).

Exercise challenge

Each participant will walk at 70 % of his/her VO2max for 20 minutes on treadmill.

Drug - Metoprolol Succinate ER

Each participant will receive metoprolol succinate starting at 50mg/day, titrated bi-weekly up to 200 mg/day for total duration of 6 weeks.

Racial Differences in the Natriuretic Peptide Response to Exercise and Beta-blockers