Dysregulation of Hormones in Obesity
common.study.values.description
“Dysregulation of FSH in Obesity: Functional and Statistical Analysis”
Excess maternal weight, especially obesity, influences almost every aspect of fertility, from conception to problems during pregnancy. The investigators will use novel statistical methods to clarify the hormonal changes behind reproductive health conditions. A better understanding of reproductive hormonal changes in obese women may offer a way to identify new treatments.
common.study.values.location
participant.ui.study.affiliations-map.online-study.header-virtual
participant.ui.study.affiliations-map.online-study.text
common.study.values.methods
common.study.methods.has-drugs-yes
common.study.methods.is-healthy-no
Drug - Degarelix (GnRH antagonist)
Day-1: Blood samples will be obtained every 10 minutes for 10 hours. After 10 hours of blood samples have been collected, the GnRH antagonist degarelix will be given subcutaneously.
Drug - recombinant FSH
Day-2: Blood samples will again be obtained every 10 minutes for 10 hours. Repeated boluses of exogenous recombinant FSH (rFSH) will be given by IV during this 10 hour visit.
participant.views.study.view.additional
participant.views.study.view.scientific-title
Dysregulation of Follicle Stimulating Hormone (FSH) in Obesity: Functional and Statistical Analysis
common.study.values.clinical-trial-id
NCT02478775
participant.views.study.view.id
zbqMkb
